GW501516
Last Post 06/03/2013 04:21 AM by Evgeni Berzin. 16 Replies.
Author Messages
Keith Richards

Posts:740

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05/16/2013 10:48 AM
Twelve days after the Colombian Marlon Perez became the sixth rider to test positive for the substance GW501516, the Venezuelan rider Miguel Ubeto Aponte has the dubious distinction of joining that list.

Read more: http://www.velonation.com/News/ID/14578/Ubeto-Aponte-latest-to-test-positive-for-GW501516-provisionally-suspended.aspx#ixzz2TT1ktIU1

The World Anti Doping Agency has issued a rare warning to all athletes not to use the substance GW501516, which it states is being sold on the black market and used by some athletes. The agency has expressed strong words of caution about the substance, which was added to the banned list three years ago.

“The side effect of this chemical compound is so serious that WADA is taking the rare step of warning “cheats” to ensure that there is complete awareness of the possible health risks to athletes who succumb to the temptation of using GW501516 for performance enhancement,” it stated in a communication.

“GW501516 was a developmental drug that was withdrawn from research by the pharmaceutical company and terminated when serious toxicities were discovered in pre-clinical studies. Clinical approval has not, and will not be given for this substance.”

Read more: http://www.velonation.com/News/ID/14196/WADA-issues-urgent-warning-about-black-market-substance-GW501516.aspx#ixzz2TT1xLdWu

Why in the hell would someone take this stuff?
----- It is his word versus ours. We like our word. We like where we stand and we like our credibility."--Lance Armstrong.
Orange Crush

Posts:1212

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05/16/2013 12:11 PM
I dunno but I'll say this; the sudden tide of central American riders doing well is a bit curious. If it was a couple sure, but a whole bunch all at the same time. Que Pasa?
Keith Richards

Posts:740

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05/16/2013 12:32 PM
They always come out to play in the Giro. Now if they are rocking and rolling in July...I will have serious questions.
----- It is his word versus ours. We like our word. We like where we stand and we like our credibility."--Lance Armstrong.
Inferno7

Posts:276

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05/16/2013 12:47 PM
How do they get their hands on these drugs? If it was a trial drug they would have to be in the trial to get it. If the trial drug fails as is the case here there are no trials, sooooo...??? Why is there any inventory of this drug anywhere, and how is it getting out of the producers control and into their hands?
Oldfart

Posts:484

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05/16/2013 01:14 PM
Keith I think it is a different kind of addiction. Why would anyone shoot up heroin? Or smoke crack? They are addicted to riding better and the adulation they get.
Orange Crush

Posts:1212

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05/16/2013 01:24 PM
Inferno - these things get quicker on the black market than they get trialed. The black market is far bigger than the legal production. Same happened with EPO, produced at about 6x the amounts than would be needed for medical purposes.
Sweet Milk

Posts:93

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05/16/2013 01:38 PM
+1 OC

I had no idea what GW501516 was so I Googled it. I found some bodybuilding sites were people were discussing it as an effective tool for 'cutting' - reading those messages it was like this stuff is the best ever, it doesn't even taste bad! (which, I guess some of the other 'supplements' do??). Not a single word about possible side effects...
Sweet Milk

Posts:93

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05/16/2013 01:39 PM
PS: No idea why some of my post is shown as quoted text ?
pikeHillRoad

Posts:95

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05/16/2013 02:01 PM
From: http://en.wikipedia.org/wiki/GW501516


In 2013 New Scientist reported that "tests on rats showed that at all doses, the drug rapidly causes cancers in a multitude of organs, including the liver, bladder, stomach, skin, thyroid, tongue, testes, ovaries and womb."[4] In 2013 WADA took the rare step of warning potential users of the compound of the possible health risks. They stated "clinical approval has not, and will not be given for this substance".[2][24]


yeah, wonder why anyone would take this stuff. crazy
Oldfart

Posts:484

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05/16/2013 03:37 PM
I met this amateur Cat 1 rider a few years back. We were I guess discussing doping. I don't really recall what we were talking about or how we got there but at one point he said: If you could take something that would almost guarantee a win and you could not get caught, wouldn't you take it? He said he would. I asked him if he would take it anyway knowing that he would probably suffer serious side effects later and would die young. he said he would take it. Dude was weird in other ways too. Reminded me of Ricco.

We don't get these guys because we are normal.
stronz

Posts:310

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05/16/2013 04:45 PM
...but really the peleton is so much cleaner now.....


what a bunch of crap. Theyre all still doing stuff. These guys who try all this $4it are morons and morally bankrupt. I am rapidly becoming of the opinion that all pro cyclists who excel in everything except maybe the one day races are by definition dopers.
longslowdistance

Posts:697

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05/20/2013 06:46 AM
Stronz, not at all arguing with your opinion that doping is still rampant, but I'd like to know how you formed this opinion. How do you know this? A long history in the sport, personal knowledge, something else?
jmdirt

Posts:708

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05/20/2013 02:50 PM
" I am rapidly becoming of the opinion that all pro cyclists who excel in everything except maybe the one day races are by definition dopers."

Why? More oxygen, more power, and better recovery after hard training rides don't help one day racers?
longslowdistance

Posts:697

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05/20/2013 04:40 PM
True dat.
Keith Richards

Posts:740

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05/20/2013 04:53 PM
I read an interview with a one-day racer about 10 years ago (I'd have to dig up the article to find out who it was) who claimed he never doped. When asked why he never excelled in stage races he simply said, "without 'proper preparation' I can only be fast enough to be competitive for 3-5 days, then I get tired."
----- It is his word versus ours. We like our word. We like where we stand and we like our credibility."--Lance Armstrong.
jacques_anquetil

Posts:222

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05/20/2013 09:00 PM
it's about the money too. ride Le Tour, or park cars down at the local Spanish steakhouse. that's a seriously tough choice.
Berzin

Posts:34

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06/03/2013 04:21 AM
Slightly off-topic question-

when the term "blood vector doping" pops up, is that just a fancy way of describing EPO abuse, or are there other drugs involved?

Because before and since its' inception, there hasn't been another drug out there that helps increase a rider's level of oxygen that I know of.

Like any other drug, the original brand (of which there were two-Epogen and Procrit, both of which were the same exact drug called epoetin alfa but marketed to different types of patients by two different companies) has gone through second, third, and fourth generation iterations, but they all do the same thing.

If GW501516 is supposed to help a rider lose weight, there are other less potentially dangerous drugs to use. Unfortunately, the anecdotal hearsay has been you can lose weight without losing any of your power. and when used in combination with AICAR, it's basically rocket fuel.

Makes sense when you see someone like Bradley Wiggins win a Tour de France, even though the 2012 edition of the race was the most boring in quite a few years (and that's saying a lot, as there have been some real snoozers the last few years) and there was no competition for him to do battle with. Please don't mention Froome, he was 3:42 seconds down on Wiggo in second place, nowhere near the yellow jersey's margin of victory.

I know there's been talk about GW501516 on some bodybuilding sites, but those dudes are crazy and they don't care-kinda like cyclists, I guess, but usually with massive dosages.

There is a drug being tested as we speak that tricks the body into thinking it's at altitude, thus mimicking the effects of EPO by raising hematocrit for patients who suffer from anemia. Then there's another that's being tested for body fat loss that won't have the same side-effects as say, clenbuterol.

So regardless of what's being taken now, there are more drugs coming down the pike that the UCI will have to contend with that will be worse than GW501516, because they will be legal and readily available.


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